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Anal cancer etiology

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  most anal cancers seem to be linked to infection with the human papillomavirus (hpv). While hpv infection seems to be important in the development of anal cancer, the vast majority of people with hpv infections do not get anal cancer. A great deal of research is now being done to learn how hpv might cause anal cancer. The anatomic definitions for anal cancer (canal versus margin) are made based on the relationship of the tumor to the anal verge. A modification in the terminology is proposed that includes intra-anal, perianal, and skin as categories. Risk factors include infection with human papillomavirus (), immunodeficiency, and receptive anal intercourse. The most common clinical features are rectal bleeding (up to 45 of cases), pruritus ani, and tenderness or pain in the anal area. Anal cancer presents mainly as squamous cell carcinoma and in rare cases as adenocarcinoma or other non-epidermoid cancers. Ajccuicc staging system edge sb, byrd dr, compton cc, et al. The american joint committee on cancer (ajcc) and the union internationale contre le cancer (uicc) developed a consensus that the anal canal extends from the anorectal ring to the anal verge.   anal cancer research has adopted terminology that mirrors the grading of cervical dysplasia (ie, cervical intraepithelial neoplasia grades i, ii,. Human papillomavirus, smoking, and sexual practices in the etiology of anal cancer.). Of all digestive system cancers in the united states, anal cancer comprises 1. The peak incidence is during the sixth decade, but the incidence of these tumors has markedly increased in younger males during the past three decades. Aetiological parallel between anal cancer and cervical cancer. Malignancies that occur before and after anal cancer clues to their etiology. Anal cancer is a cancer which arises from the anus, the distal opening of the gastrointestinal tract. Symptoms may include bleeding from the anus or a lump near the anus. Other symptoms may include pain, itchiness, or discharge from the anus. Anal cancer is an uncommon malignancy that starts in the anus-- the opening at the end of the rectum. The american society of clinical oncology estimates that 8,300 cases of anal cancer will be.

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